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Background: Being a science of beauty, beautiful smile is an integral part of contemporary dental practice. Gingival hyperpigmentation is considered an esthetic problem that needs a patient centered management. Dental operators are attracted to laser benefits not only during surgery but also for postoperative status. This review aimed to assess laser use in esthetic removal of gingival hyperpigmentation in comparison to conventional methods. Materials and Methods: An electronic database search on PubMed and Cochrane library without date restriction was done and clinical studies in which laser was used for esthetic gingival depigmentation were selected and evaluated. Out of the initial search that yielded 183 studies, 21 were considered potentially relevant for the present review, out of which only 4 were finally selected. They studied the effect of laser on depigmentation, chair time, bleeding index, patient satisfaction and repigmentation. Results: The analysis of the results shows that the assessed studies are too limited in number beside exhibiting small sample sizes. They are clinically heterogeneous so that a solid evidence based conclusion cannot be reached. Conclusion: Researchers should be attracted to this research gap. Randomized clinical trials with a larger sample size, different laser parameters and longer follow up are strongly recommended.